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|Type:||Artigo de periódico|
|Title:||Trust-region superposition methods for protein alignment|
|Abstract:||Protein alignment is a challenging applied optimization problem. Superposition methods are based on the maximization of a score function with respect to rigid-body modifications of relative positions. The problem of score maximization can be modelled as a continuous nonsmooth optimization problem (low order-value optimization (LOVO)). This allows one to define practical and convergent methods that produce monotone increases of the score. In this paper, trust-region methods are introduced for solving the problem. Numerical results are presented. Computer software related to the LOVO approach for protein alignment is available at www.ime.unicamp.br/ similar to martinez/lovoalign.|
|Editor:||Oxford Univ Press|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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