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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAge-related histopathological lesions in the Mongolian gerbil ventral prostate as a good model for studies of spontaneous hormone-related disorderspt_BR
dc.contributor.authorCampos, SGPpt_BR
dc.contributor.authorZanetoni, Cpt_BR
dc.contributor.authorScarano, WRpt_BR
dc.contributor.authorVilamaior, PSLpt_BR
dc.contributor.authorTaboga, SRpt_BR
unicamp.author.emailtaboga@ibilce.unesp.brpt_BR
unicamp.authorVilamaior, Patricia Simone Leite Taboga, Sebastiao Roberto Sao Paulo State Univ, Lab Microscopy & Microanal, Dept Biol, Inst Biosci Human & Exact Sci UNESP IBILCE, BR-15054000 Sao Jose Do Rio Preto, SP, Brazilpt_BR
unicamp.authorCampos, Silvana Gisele Pegorin Zanetoni, Cristiani Scarano, Wellerson Rodrigo State Univ Campinas UNICAMP, Inst Biol, Dept Cell Biol, Campinas, SP, Brazilpt_BR
dc.subjectageingpt_BR
dc.subjectcellular proliferationpt_BR
dc.subjectgerbilpt_BR
dc.subjectprostate cancerpt_BR
dc.subjectprostatic intraepithelial neoplasiapt_BR
dc.subjectventral prostatept_BR
dc.subject.wosLobund-wistar Ratspt_BR
dc.subject.wosMeriones-unguiculatuspt_BR
dc.subject.wosIntraepithelial Neoplasiapt_BR
dc.subject.wosSpontaneous Hyperplasiapt_BR
dc.subject.wosAndrogen Receptorpt_BR
dc.subject.wosMolecular-biologypt_BR
dc.subject.wosAbnormal Growthpt_BR
dc.subject.wosMouse Modelspt_BR
dc.subject.wosCancerpt_BR
dc.subject.wosTestosteronept_BR
dc.description.abstractThe Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the prostate lesions were evaluated morphologically, immunohistochemically and quantitatively. The most frequent changes were in epithelial sites and, namely prostatic intraepithelial neoplasias, microinvasive carcinomas and adenocarcinomas. In the stromal compartment, cellular hyperplasia, when verified, was always associated with the sites of anomalous epithelium. Additionally, larger deposition of collagen fibrils, generating stromal fibrosis, was found in all the old gerbils analysed. The quantitative analysis showed that prostatic tissue proportions differed in altered areas, being specific for each lesion type. Isolated nuclear and nucleolar parameters were not effective in diagnosing the malign potential of lesions. However, the cellular proliferation and death indexes indicated larger cellular turnover in invasive lesions such as carcinomas. With these analyses, it could be verified that old gerbils present high propensity to develop spontaneous prostate changes and this may aid in a better understanding of the biological behaviour of human prostate cancer.pt
dc.relation.ispartofInternational Journal Of Experimental Pathologypt_BR
dc.relation.ispartofabbreviationInt. J. Exp. Pathol.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherBlackwell Publishingpt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationFEBpt_BR
dc.identifier.citationInternational Journal Of Experimental Pathology. Blackwell Publishing, v. 89, n. 1, n. 13, n. 24, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume89pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage13pt_BR
dc.description.lastpage24pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn0959-9673pt_BR
dc.identifier.wosidWOS:000252261100002pt_BR
dc.identifier.doi10.1111/j.1365-2613.2007.00550.xpt_BR
dc.date.available2014-11-14T11:20:30Z
dc.date.available2015-11-26T16:06:07Z-
dc.date.accessioned2014-11-14T11:20:30Z
dc.date.accessioned2015-11-26T16:06:07Z-
dc.description.provenanceMade available in DSpace on 2014-11-14T11:20:30Z (GMT). No. of bitstreams: 1 WOS000252261100002.pdf: 1027533 bytes, checksum: 0efc601a427ac2d2be6b707ee01f4efc (MD5) Previous issue date: 2008en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:06:07Z (GMT). No. of bitstreams: 2 WOS000252261100002.pdf: 1027533 bytes, checksum: 0efc601a427ac2d2be6b707ee01f4efc (MD5) WOS000252261100002.pdf.txt: 49378 bytes, checksum: 923d40835c6a8e3a264474ec65dd377a (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76978pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/76978
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76978-
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