Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAge-related histopathological lesions in the Mongolian gerbil ventral prostate as a good model for studies of spontaneous hormone-related disorderspt_BR
dc.contributor.authorCampos, SGPpt_BR
dc.contributor.authorZanetoni, Cpt_BR
dc.contributor.authorScarano, WRpt_BR
dc.contributor.authorVilamaior, PSLpt_BR
dc.contributor.authorTaboga, SRpt_BR
unicamp.authorVilamaior, Patricia Simone Leite Taboga, Sebastiao Roberto Sao Paulo State Univ, Lab Microscopy & Microanal, Dept Biol, Inst Biosci Human & Exact Sci UNESP IBILCE, BR-15054000 Sao Jose Do Rio Preto, SP, Brazilpt_BR
unicamp.authorCampos, Silvana Gisele Pegorin Zanetoni, Cristiani Scarano, Wellerson Rodrigo State Univ Campinas UNICAMP, Inst Biol, Dept Cell Biol, Campinas, SP, Brazilpt_BR
dc.subjectcellular proliferationpt_BR
dc.subjectprostate cancerpt_BR
dc.subjectprostatic intraepithelial neoplasiapt_BR
dc.subjectventral prostatept_BR
dc.subject.wosLobund-wistar Ratspt_BR
dc.subject.wosIntraepithelial Neoplasiapt_BR
dc.subject.wosSpontaneous Hyperplasiapt_BR
dc.subject.wosAndrogen Receptorpt_BR
dc.subject.wosAbnormal Growthpt_BR
dc.subject.wosMouse Modelspt_BR
dc.description.abstractThe Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the prostate lesions were evaluated morphologically, immunohistochemically and quantitatively. The most frequent changes were in epithelial sites and, namely prostatic intraepithelial neoplasias, microinvasive carcinomas and adenocarcinomas. In the stromal compartment, cellular hyperplasia, when verified, was always associated with the sites of anomalous epithelium. Additionally, larger deposition of collagen fibrils, generating stromal fibrosis, was found in all the old gerbils analysed. The quantitative analysis showed that prostatic tissue proportions differed in altered areas, being specific for each lesion type. Isolated nuclear and nucleolar parameters were not effective in diagnosing the malign potential of lesions. However, the cellular proliferation and death indexes indicated larger cellular turnover in invasive lesions such as carcinomas. With these analyses, it could be verified that old gerbils present high propensity to develop spontaneous prostate changes and this may aid in a better understanding of the biological behaviour of human prostate
dc.relation.ispartofInternational Journal Of Experimental Pathologypt_BR
dc.relation.ispartofabbreviationInt. J. Exp. Pathol.pt_BR
dc.publisherBlackwell Publishingpt_BR
dc.identifier.citationInternational Journal Of Experimental Pathology. Blackwell Publishing, v. 89, n. 1, n. 13, n. 24, 2008.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.provenanceMade available in DSpace on 2014-11-14T11:20:30Z (GMT). No. of bitstreams: 1 WOS000252261100002.pdf: 1027533 bytes, checksum: 0efc601a427ac2d2be6b707ee01f4efc (MD5) Previous issue date: 2008en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:06:07Z (GMT). No. of bitstreams: 2 WOS000252261100002.pdf: 1027533 bytes, checksum: 0efc601a427ac2d2be6b707ee01f4efc (MD5) WOS000252261100002.pdf.txt: 49378 bytes, checksum: 923d40835c6a8e3a264474ec65dd377a (MD5) Previous issue date: 2008en
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000252261100002.pdf1 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.