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Type: Artigo de periódico
Title: Adsorption of plasma proteins to DMAA hydrogels obtained by ionizing radiation and its relationship with blood compatibility
Author: DeQueiroz, AAA
Castro, SC
Higa, OZ
Abstract: The interaction of plasma proteins such as albumin, gamma-globulin, and fibrinogen with the surface of graft copolymers DMAA-G-PTFE, DMAA-G-PETFE, and DMPLA-G-PE obtained by radiation graft polymerization was studied. The adsorption of serum proteins was affected by the hydrophilicity of the graft copolymers. Increased albumin adsorption and decreased fibrinogen and gamma-globulin adsorption with increasing grafting levels was shown. A certain range of degrees of grafting showed an improved blood compatibility of the polymeric surfaces due to the existence of a hydrophilic/hydrophobic balance on the polymers. The results suggest that the DMAA-G-PTFE, DMAA-G-PETFE, and DMAA-G-FE graft copolymers can be used as biomaterials for longterm use in cardiovascular systems.
Subject: grafting
blood compatibility
plasma proteins
protein adsorption
Country: Holanda
Editor: Vsp Bv
Rights: fechado
Identifier DOI: 10.1163/156856297X00137
Date Issue: 1997
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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