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Type: Artigo de periódico
Title: UCP2 protects hypothalamic cells from TNF-alpha-induced damage
Author: Degasperi, GR
Romanatto, T
Denis, RGP
Araujo, EP
Moraes, JC
Inada, NM
Vercesi, AE
Velloso, LA
Abstract: Uncoupling protein 2 (UCP2) is highly expressed in the hypothalamus; however, little is known about the functions it exerts in this part of the brain. Here, we hypothesized that UCP2 protects hypothalamic cells from oxidative and proapoptotic damage generated by inflammatory stimuli. Intracerebroventricular injection of tumor necrosis factor alpha (TNF-alpha)-induced an increase of UCP2 expression in the hypothalamus, which was accompanied by increased expression of markers of oxidative stress and pro-apoptotic proteins. The inhibition of UCP2 expression by an antisense oligonucleotide enhanced the damaging effects of TNF-a. Conversely, increasing the hypothalamic expression of UCP2 by cold exposure reversed most of the effects of the cytokine. Thus, UCP2 acts as a protective factor against cellular damage induced by an inflammatory stimulus in the hypothalamus. (C) 2008 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.
Subject: inflammation
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2008.08.006
Date Issue: 2008
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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