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Type: Artigo de periódico
Title: A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours
Author: Queiroz, KCD
Zambuzzi, WF
de Souza, ACS
da Silva, RA
Machado, D
Justo, GZ
Carvalho, HF
Peppelenbosch, MP
Ferreira, CV
Abstract: Riboflavin is a potent photosensitizer as well as part of the vitamin B complex. Recently we demonstrated that the products generated by irradiation of riboflavin have potential as anti-leukaemic therapy. The possible action, however, of the riboflavin photoproducts in solid cancers has not been addressed. Hence, we investigated the effects of irradiated riboflavin on androgen-independent human prostate cancer cells (PC3), a known model for solid tumour cells with an exceptional resistance to therapy. Our results show that riboflavin photoproducts are cytotoxic to these cells in a FasL-Fas-dependent manner. Furthermore, irradiated riboflavin inhibited matrix-degrading proteases, caused downregulation of VEGF and upregulation of TIMP1 suggesting anti-metastatic potential. Together, these results show that the anti-neoplastic action of riboflavin photoproducts is not limited to haematological malignancies, warranting clinical studies in solid tumours. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Subject: prostate cancer
Country: Irlanda
Editor: Elsevier Ireland Ltd
Citation: Cancer Letters. Elsevier Ireland Ltd, v. 258, n. 1, n. 126, n. 134, 2007.
Rights: fechado
Identifier DOI: 10.1016/j.canlet.2007.08.024
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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