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Type: Artigo de periódico
Title: A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma
Author: Armangue, T
Titulaer, MJ
Sabater, L
Pardo-Moreno, J
Gresa-Arribas, N
Barbero-Bordallo, N
Kelley, GR
Kyung-Ha, N
Takeda, A
Nagao, T
Takahashi, Y
Lizcano, A
Carr, AS
Graus, F
Dalmau, J
Abstract: Among 249 patients with teratoma-associated encephalitis, 211 had N-methyl-D-aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody-positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody-negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range = 12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome. ANN NEUROL 2014;75:435-441
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1002/ana.23917
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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