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Type: Artigo de periódico
Title: A new platinum complex with tryptophan: Synthesis, structural characterization, DFT studies and biological assays in vitro over human tumorigenic cells
Author: Carvalho, MA
Shishido, SM
Souza, BC
de Paiva, REF
Gomes, AF
Gozzo, FC
Formiga, ALB
Corbi, PP
Abstract: A new platinum(II) complex with the amino acid L-tryptophan (trp), named Pt-trp, was synthesized and characterized. Elemental, thermogravimetric and ESI-QTOF mass spectrometric analyses led to the composition [Pt(C11H11N2O2)(2)]center dot 6H(2)O. Infrared spectroscopic data indicate the coordination of trp to Pt(II) through the oxygen of the carboxylate group and also through the nitrogen atom of the amino group. The C-13 CP/MAS NMR spectroscopic data confirm coordination through the oxygen atom of the carboxylate group, while the N-15 CP/MAS NMR data confirm coordination of the nitrogen of the NH2 group to the metal. Density functional theory (DFT) studies were applied to evaluate the as and trans coordination modes of trp to platinum(II). The trans isomer was shown to be energetically more stable than the cis one. The Pt-trp complex was evaluated as a cytotoxic agent against SK-Mel 103 (human melanoma) and Panc-1 (human pancreatic carcinoma) cell lines. The complex was shown to be cytotoxic over the considered cells. (C) 2013 Elsevier B.V. All rights reserved.
Subject: L-Tryptophan
Molecular modeling
Antitumoral assays
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.saa.2013.11.044
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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