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Type: Artigo de periódico
Title: Voltammetric method optimized by multi-response assays for the simultaneous measurements of uric acid and acetaminophen in urine in the presence of surfactant using MWCNT paste electrode
Author: Hudari, FF
Duarte, EH
Pereira, AC
Dall'Antonia, LH
Kubota, LT
Tarley, CRT
Abstract: In the present study, an electroanalytical method for the simultaneous determination of acetaminophen (AC) and uric acid (UA) in urine samples with a carbon nanotube paste electrode (CNTPE) employing a cationic surfactant (cetylpyridinium bromide, CPB) was developed. The optimization of the proposed differential pulse voltammetric method was performed by means of multi-response assays, highly recommended for simultaneous analysis. Under optimized conditions (pH 7.7, phosphate concentration of 0.1 mol L-1, pulse amplitude of 123 mV, modulation time of 5 ms, CPB concentration of 0.30 mmol L-1 and scan rate of 100 mV s(-1)), a remarkable peak separation of UA and AC at 174 mV was achieved. The linear curves for the simultaneous determination of UA and AC were built in concentration range of 5.0-92.6 mu mol L-1 with satisfactory regression of 0.995 for UA and 0.999 for AC. Limits of detection were found to be 0.25 and 0.57 mu mol L-1 for UA and AC, respectively, and the precision assessed as relative standard deviation (RSD) for ten determinations was found to be 3.20% and 1.34% for respective concentrations of 10.0 and 72.5 mu mol L-1 for UA and 4.3% and 1.6% for AC. The electrochemical sensor with antifouling features was successfully applied for the free-interference simultaneous determination of UA and AC in urine samples. (C) 2013 Elsevier B.V. All rights reserved.
Subject: Carbon nanotubes
Factorial design
Voltammetric sensor
Urine samples
Uric acid
Country: Suíça
Editor: Elsevier Science Sa
Citation: Journal Of Electroanalytical Chemistry. Elsevier Science Sa, v. 696, n. 52, n. 58, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.jelechem.2013.01.033
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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