Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Comparison of the effects of pilocarpine and cevimeline on salivary flow|
|Author:||BRAGA, M. A.|
BERGAMASCHI, C. C.
SANTOS, F. A.
ANDRADE, E. D.
GROPPO, F. C.
|Abstract:||Objective: The aim of the present study was to compare the effect of low-dose pilocarpine and cevimeline as stimulants for salivary flow in healthy subjects. Methods: In this cross-over clinical trial with a 1-week washout period, 40 male volunteers were submitted to an oral dose of pilocarpine 1% (Salagen (TM)) -60 mu g kg(-1) body-weight (Group 1) or Cevimeline (Evoxac (TM)) -30 mg (Group 2). Saliva samples were collected and the salivary flow rate was measured (ml min(-1)) at baseline and 20, 40, 60, 80, 140 and 200 min after administration of drugs. In addition, salivary secretion was also measured under mechanical stimulation to observe salivary gland function. Results: The data were analyzed by Friedman and Wilcoxon signed-rank tests (significance level = 5%). Pilocarpine and cevimeline significantly increased salivary flow 140 min after intake. There was a significant higher secretion with cevimeline 140 and 200 min after administration. There were no differences seen among subjects in the salivary glands function by mechanical stimulation. Conclusion: Both drugs showed efficacy in increasing the salivary flow in healthy volunteers, but cevimeline was more effective than pilocarpine.|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
Files in This Item:
|art_BRAGA_Comparison_of_the_effects_of_pilocarpine_and_2009.pdf||published version||95.04 kB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.