Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/762
Type: Artigo de periódico
Title: Comparison of the effects of pilocarpine and cevimeline on salivary flow
Author: BRAGA, M. A.
TARZIA, O.
BERGAMASCHI, C. C.
SANTOS, F. A.
ANDRADE, E. D.
GROPPO, F. C.
Abstract: Objective: The aim of the present study was to compare the effect of low-dose pilocarpine and cevimeline as stimulants for salivary flow in healthy subjects. Methods: In this cross-over clinical trial with a 1-week washout period, 40 male volunteers were submitted to an oral dose of pilocarpine 1% (Salagen (TM)) -60 mu g kg(-1) body-weight (Group 1) or Cevimeline (Evoxac (TM)) -30 mg (Group 2). Saliva samples were collected and the salivary flow rate was measured (ml min(-1)) at baseline and 20, 40, 60, 80, 140 and 200 min after administration of drugs. In addition, salivary secretion was also measured under mechanical stimulation to observe salivary gland function. Results: The data were analyzed by Friedman and Wilcoxon signed-rank tests (significance level = 5%). Pilocarpine and cevimeline significantly increased salivary flow 140 min after intake. There was a significant higher secretion with cevimeline 140 and 200 min after administration. There were no differences seen among subjects in the salivary glands function by mechanical stimulation. Conclusion: Both drugs showed efficacy in increasing the salivary flow in healthy volunteers, but cevimeline was more effective than pilocarpine.
Subject: cevimeline
clinical trial
human subjects
pilocarpine
salivary flow
Country: Estados Unidos
Editor: WILEY-BLACKWELL
Citation: INTERNATIONAL JOURNAL OF DENTAL HYGIENE, v.7, n.2, p.126-130, 2009
Rights: fechado
Identifier DOI: 10.1111/j.1601-5037.2008.00326.x
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000207895000008&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.1111/j.1601-5037.2008.00326.x
Date Issue: 2009
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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