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Type: Artigo de periódico
Title: A Morita-Baylis-Hillman adduct allows the diastereoselective synthesis of styryl lactones
Author: Paioti, PHS
Coelho, F
Abstract: We disclosed herein a diastereoselective approach for the total syntheses of (+/-)-Leiocarpin A and (+/-)-Goniodiol. These biologically active styryl lactones were obtained from a common intermediate, prepared in five steps and 40% overall yield, using a simple synthetic sequence starting from a Morita-Baylis-Hillman adduct. The total syntheses of these styryl lactones were accomplished in nine steps. This is the first report on the total synthesis of this class of natural products starting from Morita-Baylis-Hillman adduct. (C) 2011 Elsevier Ltd. All rights reserved.
Subject: Leiocarpin A
Ring closing metathesis
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 52, n. 46, n. 6180, n. 6184, 2011.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2011.09.044
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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