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Type: Artigo de periódico
Title: A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
Author: Torre, LG
Carneiro, AL
Rosada, RS
Silva, CL
Santana, MHA
Abstract: Cationic liposomes are an alternative to DNA non-viral carrier in gene therapy, promoting higher efficiency for DNA transport and delivery into the cells. Liposome production in large scale is still a challenge. Among many processes, the liposome production front a dried film adsorbed inside a multitubular system is promising due to its operational simplicity. In this field, engineering contributions are scarce and no mathematical treatment in the literature describing the liposome production in this type of process is available. A mathematical formulation is proposed to describe the kinetic of liposome production considering the wetting and disintegration of the dried lipid film followed by lipids aggregation into bilayers generating liposomes. The proposed model has fitted the experimental kinetic data of lipid mass disintegration and the lipid film thickness, being useful for predictions of the scaling up of liposome production as well as contributing to the development of pharmaceutical products.
Subject: liposomes
mathematical modeling
Country: Brasil
Editor: Brazilian Soc Chemical Eng
Rights: aberto
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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