Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/75987
Type: Artigo de periódico
Title: Zoledronic acid decreases gene expression of vascular endothelial growth factor and basic fibroblast growth factor by human epithelial cells
Author: Basso, FG
Turrioni, APS
Hebling, J
Costa, CAD
Abstract: Delayed wound healing in patients taking bisphosphonates could result from decreased expression of growth factors, which are directly related to cell proliferation and migration. In this study, we evaluated the gene expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bEGF) by epithelial cells exposed to zoledronic acid 5 mu mol for 48 h using real-time polymerase chain reaction. The gene expression of VEGF and bFGF by epithelial cells exposed to zoledronic acid decreased by 34% and 51%, respectively (p=0.0001 and p=0.0001). We conclude that zoledronic acid can decrease the expression of growth factors by epithelial cells. (C) 2013 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Subject: Epithelial cells
VEGF
bFGF
Tissue healing
Bisphosphonates
Country: Escócia
Editor: Churchill Livingstone
Rights: fechado
Identifier DOI: 10.1016/j.bjoms.2013.05.010
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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