Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/75912
Type: Artigo de periódico
Title: A HISTOPATHOLOGIC STUDY OF THE MECHANISM OF EVANS BLUE STAINING OF MYOCARDIAL INFARCTS IN RATS
Author: CURTI, HJV
WIEZEL, PHM
LIMA, MAA
FERREIRA, MCF
RINCON, MCA
Abstract: In a study of the mechanism of Evans blue (EB) staining of experimental infarcts in rats, it has been reported that when the dye was injected iv before left coronary occlusion (LCO) it diffused centripetally from the periphery of the excluded vascular bed region (ExVB), i.e., the myocardial area with circulation interrupted by LCO, to its center. In the present study, we have attempted to identify the mechanism of this phenomenon. The animals were sacrificed at different times after EB injection, i.e., 10, 20, and 30 min and 1, 2.5, 4.5, 6, 16, 24 and 48 h. This phenomenon occurred from 4.5 up to 24 h after LCO and could not be ascribed to either collateral circulation or to venous backflow. We conclude that diffusion from one necrotic cell to another, beginning at the ill-perfused periphery of the ExVB (lateral and endocardial margins of the ExVB), and also at the epicardium (bathed by pericardial effusion rich in EB) is responsible for the production of the so-called 'blue infarct'.
Subject: MYOCARDIAL INFARCT
LEFT CORONARY OCCLUSIONS
EVANS BLUE
BLUE INFARCT
Country: Brasil
Editor: Assoc Bras Divulg Cientifica
Rights: aberto
Date Issue: 1991
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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