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Type: Artigo de periódico
Title: Role of ultrasound, clinical and scintigraphyc parameters to predict malignancy in thyroid nodule
Author: Maia, FFR
Matos, PS
Silva, BP
Pallone, AT
Pavin, EJ
Vassallo, J
Zantut-Wittmann, DE
Abstract: Background: This study aimed to evaluate clinical, laboratory, ultrasound (US) and scintigraphyc parameters in thyroid nodule and to develop an auxiliary model for clinical application in the diagnosis of malignancy. Methods: We assessed 143 patients who were surgically treated at a single center, 65% (93) benign vs. 35% (50) malignant lesions at final histology (1998-2008). The clinical, laboratory, scintigraphyc and US features were compared and a prediction model was designed after the multivariate analysis. Results: There were no differences in gender, serum TSH and FT4 levels, thyroid auto-antibodies (TAb), thyroid dysfunction and scintigraphyc results (P = 0.33) between benign and malignant nodule groups. The sonographic study showed differences when the presence of suspected characteristics was found in the nodules of the malignant lesions group, such as: microcalcifications, central flow, border irregularity and hypoechogenicity. After the multivariate analysis the model obtained showed age (>39 years), border irregularity, microcalcifications and nodule size over 2 cm as predictive factors of malignancy, featuring 81.7% of accuracy. Conclusions: This study confirmed a significant increase of risk for malignancy in patients of over 39 years and with suspicious features at US.
Country: Inglaterra
Editor: Biomed Central Ltd
Citation: Head & Neck Oncology. Biomed Central Ltd, v. 3, 2011.
Rights: aberto
Identifier DOI: 10.1186/1758-3284-3-17
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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