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Type: Artigo
Title: Role of the hippocampus in contextual memory after classical aversive conditioning in pigeons (C-livia)
Author: Reis, F.
Ferrari, E.A.M.
Schenka, A.A.
Melo, L.L.
Abstract: We investigated the effects of hippocampal lesions with ibotenic acid (IBO) on the memory of the sound-context-shock association during reexposure to the conditioning context. Twenty-nine adult pigeons were assigned to a non-lesioned control group (CG, N = 7), a sham-lesioned group (SG, N = 7), a hippocampus-lesioned experimental group (EG, N = 7), and to an unpaired nonlesioned group (tone-alone exposure) (NG, N = 8). All pigeons were submitted to a 20-min session in the conditioning chamber with three associations of sound (1000 Hz, 85 dB, 1 s) and shock (10 mA, 1 s). Experimental and sham lesions were performed 24 h later (EG and SG) when EG birds received three bilateral injections (anteroposterior (A), 4.5, 5.25 and 7.0) of IBO (1 mu l and 1 mu g/mu l) and SG received one bilateral injection (A, 5.25) of PBS. The animals were reexposed to the training context 5 days after the lesion. Behavior was videotaped for 20 min and analyzed at 30-s intervals. A significantly higher percent rating of immobility was observed for CG (median, 95.1; range, 79.2 to 100.0) and SG (median, 90.0; range, 69.6 to 95.0) compared to EG (median, 11.62; range, 3.83 to 50.1) and NG (median, 7.33; range, 6.2 to 28.1) (P<0.001) in the training context. These results suggest impairment of contextual fear in birds who received lesions one day after conditioning and a role for the hippocampus in the modulation of emotional aversive memories in pigeons
Subject: Hipocampo
Country: Brasil
Editor: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 32, n. 9, n. 1127, n. 1131, 1999.
Rights: Aberto
Identifier DOI: 10.1590/S0100-879X1999000900012
Date Issue: 1999
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos

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