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Type: Artigo de periódico
Title: Sesquiterpene lactones from Vernonia scorpioides and their in vitro cytotoxicity
Author: Buskuhl, H
de Oliveira, FL
Blind, LZ
de Freitas, RA
Barison, A
Campos, FR
Corilo, YE
Eberlin, MN
Caramori, GF
Biavatti, MW
Abstract: Fresh leaves of Vernonia scorpioides are widely used in Brazil to treat a variety of skin disorders. Previous in vivo studies with extracts of this species had also demonstrated a high antitumor potential. This paper reports isolation of four sesquiterpene lactones (hirsutinolides and glaucolides), together with diacetylpiptocarphol, 8-acetyl-13-etoxypiptocarphol, luteolin, apigenin, and ethyl caffeate from fresh leaves and flowers of Vernonia scorpioides. The hypothesis that hirsutinolide 3 is formed during extraction was verified theoretically using Density Functional Theory. The effects of isolated compounds on in vitro tumor cells were investigated, as well as their genotoxicity by means of an in vitro comet assay. The results indicate that glaucolide 2 and hirsutinolide 4 are toxic to HeLa cells. These compounds were genotoxic in vitro, a property that appears to be related to the presence of their epoxy groups, which has been a more reliable indication of toxicity than substitution on C-13 or the presence of alpha,beta-unsaturated keto-groups. These results need to be replicated in vivo in order to ascertain their toxicity. (C) 2010 Elsevier Ltd. All rights reserved.
Subject: Vernonia scorpioides
Piptocarphol esters
Ethyl caffeate
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Phytochemistry. Pergamon-elsevier Science Ltd, v. 71, n. 13, n. 1539, n. 1544, 2010.
Rights: fechado
Identifier DOI: 10.1016/j.phytochem.2010.06.007
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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