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Type: Artigo de periódico
Title: Serum levels of interleukin-6 (II-6), interleukin-18 (II-18) and c-reactive protein (CRP) in patients with type-2 diabetes and acute coronary syndrome without ST-Segment elevation
Author: Souza, JRM
Oliveira, RT
Blotta, MHSL
Coelho, OR
Abstract: Background. Atherosclerosis is an inflammatory disease, and serum levels of inflammatory markers such as interleukin 6 (IL-6), interleukin 18 (IL-18) and C-reactive protein (CRP) are used to evaluate patients with coronary artery disease. In patients with type-2 diabetes, atherosclerosis is related to a larger number of events such as myocardial infarction and death, when compared with patients without diabetes. Objective: To evaluate the inflammatory response in patients with diabetes and acute events of coronary instability. Methods: Two groups of patients were primarily selected. The first group was comprised of diabetic outpatients with stable angina (D-CCS) and presence of coronary artery disease on coronary angiography (n =36). The second group was comprised of diabetic patients seen in the emergency room with acute coronary syndrome (D-ACS) without ST-segment elevation (n=38). Non-diabetic patients with ACS (n=22) and CCS (n = 16) comprised the control group. Serum levels of CRP IL-6 and IL-18 were determined using nephelometry (CRP) and ELISA (IL-6 and IL-18) techniques. Results: Higher serum IL-6 levels were found in diabetic or non-diabetic patients with ACS than in the group with CCS. On the other hand, diabetic patients with ACS had higher CRP levels in comparison with the other groups. Serum IL-18 levels were not significantly different among the patients studied. Conclusion: our findings suggest a more intense inflammatory activity in patients with coronary instability This inflammatory activity, as measured by CRP seems to be even more intense in diabetic patients. (Arq Bras Cardiol 2008;90(2):86-90).
Subject: interleukin-6
coronary arteriosclerosis
diabetes mellitus
Country: Brasil
Editor: Arquivos Brasileiros Cardiologia
Rights: aberto
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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