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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSerum leptin and insulin levels in lactating protein-restricted rats: implications for energy balancept_BR
dc.contributor.authorFerreira, CLPpt_BR
dc.contributor.authorMacedo, GMpt_BR
dc.contributor.authorLatorraca, MQpt_BR
dc.contributor.authorArantes, VCpt_BR
dc.contributor.authorVeloso, RVpt_BR
dc.contributor.authorCarneiro, EMpt_BR
dc.contributor.authorBoschero, ACpt_BR
dc.contributor.authorNascimento, CMOpt_BR
dc.contributor.authorGaiva, MHpt_BR
unicamp.author.emailmarihele@cpd.ufmt.brpt_BR
unicamp.authorUniv Fed Mato Grosso, Fac Nutr, Dept Alimentos & Nutr, Cuiaba, MT, Brazil Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, Campinas, SP, Brazil Univ Fed Sao Paulo, Dept Fisiol Nutr, Sao Paulo, SP, Brazilpt_BR
dc.subjectlow-protein dietpt_BR
dc.subjectserum leptinpt_BR
dc.subjectserum insulinpt_BR
dc.subjectenergy balancept_BR
dc.subjectlactationpt_BR
dc.subject.wosAdipose-tissuept_BR
dc.subject.wosMilk-productionpt_BR
dc.subject.wosPregnancypt_BR
dc.subject.wosDietspt_BR
dc.subject.wosThermogenesispt_BR
dc.subject.wosRodentspt_BR
dc.subject.wosHyperphagiapt_BR
dc.subject.wosEnergeticspt_BR
dc.subject.wosPlasmapt_BR
dc.description.abstractThe present study analysed the effect of protein restriction on serum insulin and leptin levels and their relationship with energy balance during lactation. Four groups of rats received isocaloric diets containing 170 g protein/kg or 60 g protein/kg from pregnancy until the 14th day of lactation: control non-lactating, control lactating (both fed a control diet), low-protein non-lactating and low-protein lactating. Energy intake, body composition, energy balance. serum insulin and leptin concentrations and the relationship between these hormones and several factors related to obesity were analysed. Low-protein-intake lactating rats exhibited hypoinsulinaemia, hyperleptinaemia, hypophagia and decreased energy expenditure compared with control lactating rats. The protein level in the carcasses was lower in the low-protein lactating group than in the control lactating group, resulting in a higher fat content in the first group compared with the latter. Body fat correlated inversely with serum insulin and positively with serum leptin level. There was a significant negative correlation between serum leptin and energy intake, and a positive relationship between energy intake and serum insulin level in lactating rats and in the combined data from both groups. Energy expenditure was correlated positively with serum insulin and negatively with serum leptin in lactating rats and when data from control non-lactating and lactating rats were pooled. Lactating rats submitted to protein restriction, compared with lactating control rats, showed that maternal reserves were preserved owing to less severe negative energy balance. This metabolic adaptation was obtained, at least in part, by the hypoinsulinaemia that resulted in increased insulin sensitivity favouring enhanced fat deposition, hyperleptinaemia and hypophagia.pt
dc.description.noteo TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.pt
dc.relation.ispartofBritish Journal Of Nutritionpt_BR
dc.relation.ispartofabbreviationBr. J. Nutr.pt_BR
dc.publisher.cityCambridgept_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherCambridge Univ Presspt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationJANpt_BR
dc.identifier.citationBritish Journal Of Nutrition. Cambridge Univ Press, v. 97, n. 1, n. 27, n. 34, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume97pt_BR
dc.description.issuenumber1pt_BR
dc.description.initialpage27pt_BR
dc.description.lastpage34pt_BR
dc.rightsembargopt_BR
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676pt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0007-1145pt_BR
dc.identifier.wosidWOS:000244148700006pt_BR
dc.identifier.doi10.1079/S0007114507106863pt_BR
dc.date.available2014-11-14T05:04:58Z
dc.date.available2015-11-26T16:04:39Z-
dc.date.accessioned2014-11-14T05:04:58Z
dc.date.accessioned2015-11-26T16:04:39Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:04:39Z (GMT). No. of bitstreams: 2 WOS000244148700006.pdf: 116534 bytes, checksum: 2767efc6c9c4b516b67736b541143ba4 (MD5) WOS000244148700006.pdf.txt: 44014 bytes, checksum: a617efdc74849d8bc745f7f8f69e4418 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75670pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/75670
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75670-
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