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Type: Artigo de periódico
Title: Serum high-density lipoprotein (HDL) inhibits in vitro enterohemolysin (EHly) activity produced by enteropathogenic Escherichia coli
Author: Figueiredo, PMS
Catani, CF
Yano, T
Abstract: Enterohemolysin (EHly) produced by Escherichia coli shows hemolytic activity towards washed erythrocytes from different animal species on blood agar plates. It has been shown recently that EHly activity is inhibited by normal mammalian serum and by cholesterol in vitro. Plasma lipoproteins can interact with bacterial toxins, such as endotoxin, to reduce their toxicity. In this work, we examine the ability of human purified chylomicrons, very low-density lipoproteins, intermediate-density, low-density and high-density lipoproteins, to inhibit the hemolytic activity of EHly. Our results show that these lipoproteins are hemolysin inactivators, and that high-density lipoprotein is the most potent inhibitor of enterohemolytic activity. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Subject: Escherichia coli
Country: Holanda
Editor: Elsevier Science Bv
Citation: Fems Immunology And Medical Microbiology. Elsevier Science Bv, v. 38, n. 1, n. 53, n. 57, 2003.
Rights: fechado
Identifier DOI: 10.1016/S0928-8244(03)00125-1
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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