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Type: Artigo de periódico
Title: Glial fibrillary acidic protein in tumor types with cartilaginous differentiation
Author: SANTOS, Giscle Caravina
CARVALHO, Katia Candido
FALZONI, Roberto
SIMOES, Ana Carolina Q.
ROCHA, Rafael Malagoli
LOPES, Ademar
REIS, Luiz Fernando Lima
SOARES, Fernando Augusto
CUNHA, Isabela Werneck da
Abstract: Glial fibrillary acidic protein (GFAP) is a member of the intermediary filament protein family. It is an important component of astrocytes and a known diagnostic marker of glial differentiation. GFAP is expressed in other neural tumors and pleomorphic adenoma and, less frequently, in cartilage tumors, chordomas, and soft tissue myoepitheliomas. The aim of this study was to evaluate the role of GFAP and its reliability in nonglial tumors as an immunohistochemical marker. We evaluated GFAP gene and protein expression using Q-PCR and immunohistochemistry, respectively, in 81 and 387 cases of soft tissue, bone tumors, and salivary pleomorphic adenomas. Immunohistochemistry staining for GFAP was observed in all osteosarcomas (8 cases), all pleomorphic adenomas (7 cases), in 5 of 6 soft tissue myoepitheliomas, and in 21 of 76 chondrosarcomas. By Q-PCR, GFAP was highly expressed in pleomorphic adenomas and, to a lesser extent, chondrosarcomas, soft tissue myoepitheliomas, and chondroblastic osteosarcomas. The results that we obtained by immunohistochemistry and Q-PCR were well correlated. GFAP is a potential marker for tumors with cartilaginous differentiation, supported by evidence that GFAP is expressed in certain cases of myoepithelial tumors by immunohistochemistry, including soft tissue myoepitheliomas, which are related to cartilaginous differentiation. These findings contribute significantly to the diagnosis of soft tissue myoepitheliomas with cartilaginous differentiation and chondroblastic osteosarcoma in mesenchymal tumors. Modern Pathology ( 2009) 22, 1321-1327; doi: 10.1038/modpathol.2009.99; published online 7 August 2009
Subject: mesenchymal tumors
cartilaginous differentiation
Country: Estados Unidos
Citation: MODERN PATHOLOGY, v.22, n.10, p.1321-1327, 2009
Rights: fechado
Identifier DOI: 10.1038/modpathol.2009.99
Date Issue: 2009
Appears in Collections:FCM - Artigos e Outros Documentos

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