Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/755
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.subject.otherMATRIX METALLOPROTEINASE-8 MMP-8en
dc.subject.otherRESISTANT ACID-PHOSPHATASEen
dc.subject.otherSELF-ETCHING ADHESIVESen
dc.subject.otherCOLLAGENOLYTIC ACTIVITYen
dc.subject.otherCARIES PROGRESSIONen
dc.subject.otherHUMAN ODONTOBLASTSen
dc.subject.otherRADICULAR DENTINen
dc.subject.otherRAT INCISORen
dc.subject.otherIN-VIVOen
dc.subject.otherDEGRADATIONen
dc.typeArtigo de periódicopt_BR
dc.type.categoryoriginal articlept_BR
dc.type.versionpublishedVersionpt_BR
dc.titleCysteine Cathepsins in Human Dentin-Pulp Complexpt_BR
dc.contributor.authorTERSARIOL, Ivarne L.pt_BR
dc.contributor.authorGERALDELI, Saulopt_BR
dc.contributor.authorMINCIOTTI, Christiane L.pt_BR
dc.contributor.authorNASCIMENTO, Fabio D.pt_BR
dc.contributor.authorPAAKKONEN, Virvept_BR
dc.contributor.authorMARTINS, Marilia T.pt_BR
dc.contributor.authorCARRILHO, Marcela R.pt_BR
dc.contributor.authorPASHLEY, David H.pt_BR
dc.contributor.authorTAY, Franklin R.pt_BR
dc.contributor.authorSALO, Tuulapt_BR
dc.contributor.authorTJADERHANE, Leopt_BR
unicamp.authorCARRILHO, Marcela R.:Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Departamento de Odontologia Restauradorapt_BR
unicamp.author.externalTERSARIOL, Ivarne L.pt
unicamp.author.externalGERALDELI, Saulopt
unicamp.author.externalMINCIOTTI, Christiane L.pt
unicamp.author.externalNASCIMENTO, Fabio D.pt
unicamp.author.externalPAAKKONEN, Virvept
unicamp.author.externalPASHLEY, David H.pt
unicamp.author.externalTAY, Franklin R.pt
unicamp.author.externalSALO, Tuulapt
unicamp.author.externalTJADERHANE, Leopt
unicamp.author.externalMARTINS, Marilia T.pt
dc.subjectEnzymept_BR
dc.subjecthumanpt_BR
dc.subjectMMPpt_BR
dc.subjectodontoblastpt_BR
dc.subjecttoothpt_BR
dc.subject.wosDentistry, Oral Surgery & Medicinept_BR
dc.description.abstractIntroduction: Collagen-degrading matrix metalloproteinases (MMPs) are expressed by odontoblasts and present in dentin. We hypothesized that odontoblasts express other collagen-degrading enzymes such as cysteine cathepsins, and their activity would be present in dentin, because odontoblasts are known to express at least cathepsin D. Effect of transforming growth factor beta (TGF-beta) on cathepsin expression was also analyzed. Methods: Human odontoblasts and pulp tissue were cultured with and without TGF-beta, and cathepsin gene expression was analyzed with DNA microarrays. Dentin cathepsin and MMP activities were analyzed by degradation of respective specific fluorogenic substrates. Results: Both odontoblasts and pulp tissue demonstrated a wide range of cysteine cathepsin expression that gave minor responses to TGF-beta. Cathepsin and MMP activities were observed in all dentin samples, with significant negative correlations in their activities with tooth age. Conclusions: These results demonstrate for the first time the presence of cysteine cathepsins in dentin and suggest their role, along with MMPs, in dentin modification with aging. (J Endod 2010;36:475-481)en
dc.relation.ispartofJournal of Endodonticspt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherELSEVIER SCIENCE INCpt_BR
dc.date.issued2010pt_BR
dc.identifier.citationJOURNAL OF ENDODONTICS, v.36, n.3, p.475-481, 2010pt_BR
dc.language.isoengpt_BR
dc.description.volume36pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage475pt_BR
dc.description.lastpage481pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright ELSEVIER SCIENCE INCpt_BR
dc.sourceWOSpt_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0099-2399pt_BR
dc.identifier.doi10.1016/j.joen.2009.12.034pt_BR
dc.identifier.urlhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000279279600017&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecordpt_BR
dc.identifier.urlhttp://dx.doi.org/10.1016/j.joen.2009.12.034pt_BR
dc.description.sponsorshipAcademy of Finland[111724]pt_BR
dc.description.sponsorshipFinnish Dental Society Apolloniapt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2013-07-26T17:58:27Z
dc.date.available2016-06-30T20:30:50Z-
dc.date.accessioned2013-07-26T17:58:27Z
dc.date.accessioned2016-06-30T20:30:50Z-
dc.description.provenanceMade available in DSpace on 2013-07-26T17:58:27Z (GMT). No. of bitstreams: 2 art_TERSARIOL_Cysteine_Cathepsins_in_Human_Dentin-Pulp_Complex_2010.pdf.txt: 39073 bytes, checksum: df60c459e6ba185ae306fa974a916024 (MD5) art_TERSARIOL_Cysteine_Cathepsins_in_Human_Dentin-Pulp_Complex_2010.pdf: 532718 bytes, checksum: cb6fd9b3cff3cdbbee37d7c54fb9bb25 (MD5) Previous issue date: 2010en
dc.description.provenanceMade available in DSpace on 2016-06-30T20:30:50Z (GMT). No. of bitstreams: 2 art_TERSARIOL_Cysteine_Cathepsins_in_Human_Dentin-Pulp_Complex_2010.pdf.txt: 39073 bytes, checksum: df60c459e6ba185ae306fa974a916024 (MD5) art_TERSARIOL_Cysteine_Cathepsins_in_Human_Dentin-Pulp_Complex_2010.pdf: 532718 bytes, checksum: cb6fd9b3cff3cdbbee37d7c54fb9bb25 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/755
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/755-
dc.contributor.departmentOdontologia Restauradora
dc.contributor.unidadeFOPpt
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