Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/75558
Type: Artigo de periódico
Title: SICKLE-CELL DISEASE IN A BRAZILIAN POPULATION FROM SAO-PAULO - A STUDY OF THE BETA(S) HAPLOTYPES
Author: GONCALVES, MS
NECHTMAN, JF
FIGUEIRERDO, MS
KERBAUY, J
ARRUDA, VR
SONATI, MF
SAAD, SOT
COSTA, FF
STOMING, TA
Abstract: In this study we have determined the frequency of beta(s) haplotypes in a Brazilian sickle cell disease population from Sao Paulo, Brazil, by analyzing sequence variations in the immediate 5' flanking and second intervening sequence (IVSII) regions of the gamma globin genes. This association between sequence differences and beta(s) haplotype backgrounds was determined by screening genomic DNA samples using dot blot analysis of polymerase chain reaction products. We studied 148 beta(s) chromosomes, and found that haplotype 20 (CAR or Bantu) signif icantly predominated in this population. This is in agreement with the findings of the historical Portuguese Atlantic slave
Subject: B-S HAPLOTYPES
(G)GAMMA GLOBIN GENE
BRAZIL
Country: Suíça
Editor: Karger
Rights: fechado
Identifier DOI: 10.1159/000154238
Date Issue: 1994
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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