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Type: Artigo de periódico
Title: Short total synthesis of aspartyl protease inhibitors L-685,434, L-682,679 and L-685,458
Author: Dias, LC
Ferreira, AA
Diaz, G
Abstract: Hydroxyethylene dipeptide isosteres L-685,434, L682,679 and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with an alpha-aminoaldehyde followed by hydroboration of the corresponding 1,2syn and 1,2-anti aminoalcohols to give the diols, lactonization under TPAP conditions, lactone opening and peptide coupling with the desired amine or dipeptide amide.
Subject: amino aldehydes
total synthesis
Country: Alemanha
Editor: Georg Thieme Verlag Kg
Rights: embargo
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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