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|Type:||Artigo de periódico|
|Title:||Short total synthesis of aspartyl protease inhibitors L-685,434, L-682,679 and L-685,458|
|Abstract:||Hydroxyethylene dipeptide isosteres L-685,434, L682,679 and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with an alpha-aminoaldehyde followed by hydroboration of the corresponding 1,2syn and 1,2-anti aminoalcohols to give the diols, lactonization under TPAP conditions, lactone opening and peptide coupling with the desired amine or dipeptide amide.|
|Editor:||Georg Thieme Verlag Kg|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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