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Type: Artigo de periódico
Title: Short synthesis of methylphenidate and its p-methoxy derivative
Author: Dias, LC
Fernandes, AMAD
Abstract: A short method for the preparation of racemic threo- and erythro-methylphenidate derivatives is described. Condensation between a-ethoxy carbamate 1 and silyl ketene acetals 2a-b in the presence of TESOTf (20 mol%) afforded a 1.5:1 mixture of carbamates 3a-b/4a-b. Hydrogenolysis in EtOH followed by treatment with 3N HCl/MeOH afforded the corresponding hydrochlorides 7a-b/8a-b in good yields.
Country: EUA
Editor: Marcel Dekker Inc
Rights: fechado
Identifier DOI: 10.1080/00397910008087153
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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