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|Type:||Artigo de periódico|
|Title:||Short synthesis of methylphenidate and its p-methoxy derivative|
|Abstract:||A short method for the preparation of racemic threo- and erythro-methylphenidate derivatives is described. Condensation between a-ethoxy carbamate 1 and silyl ketene acetals 2a-b in the presence of TESOTf (20 mol%) afforded a 1.5:1 mixture of carbamates 3a-b/4a-b. Hydrogenolysis in EtOH followed by treatment with 3N HCl/MeOH afforded the corresponding hydrochlorides 7a-b/8a-b in good yields.|
|Editor:||Marcel Dekker Inc|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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