Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Study of the reactivity of alpha-acylenaminoketones. Synthesis of pyrazoles|
|Abstract:||The reactions of 4-(methylamino)-3-penten-2-one with diazoketones yielded the alpha -acylenaminoketones 1-3 in good yields. Preparation of the alpha -acylenaminoketone 4 was carried out by treatment of 4-(t-butylamino)-3-penten-2-one with benzoyl chloride being followed by reaction of transamination with methylamine. The reactions were carried out in five different solvents land were submitted to gas chromatography/mass spectrometry analysis, with the goal of obtaining substituted pyrazoles and determining which of the carbonyls would preferentially be attacked by the nucleophile. The reactions of compounds 1-4 with hydrazine reagents led to the formation of the pyrazoles 5-7a-q. Small amounts of 4-methylamino-2-pentenones 10a-q, amides 11a-q and pyrazoles 12a-q were also obtained in these reactions. The unexpected formation of pyrazoles 15d,h,q was detected when methanol and N,N-dimethylformamide were used as solvents in the reactions of alpha -acylenaminoketone 4 with hydrazine reagents.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.