Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/753
Type: Artigo de periódico
Title: Cigarette smoke inhalation modulates gene expression in sites of bone healing: a study in rats
Author: GIORGETTI, Ana Paula Oliveira
CESAR NETO, Joao Batista
RUIZ, Karina Gonzales Silverio
CASATI, Marcio Zaffalon
SALLUM, Enilson Antonio
NOCITI JR., Francisco Humberto
Abstract: Objective. The aim of this study was to assess the effect of cigarette smoke inhalation (CSI) on gene expression in alveolar bone healing sites. Study design. Wistar rats were randomly assigned to the groups: control [animals not exposed to CSI (n = 20)] and test [animals exposed to CSI, starting 3 days before teeth extraction and maintained until killing them (n = 20)]. First mandibular molars were bilaterally extracted, and the expression of alkaline phosphatase, bone morphogenetic protein (BMP) 2 and 7, receptor activator of nuclear factor kappa B ligand, osteoprotegerin, and d2 isoform of vacuolar adenosine triphosphatase V(o) domain were assessed by quantitative polymerase chain reaction in the newly formed tissue in the sockets. Results. Overall, data analysis demonstrated that CSI significantly affected the expression pattern of all of the studied genes except BMP-7. Conclusion. The expression of key genes for bone healing may be affected by CSI in tooth extraction sites. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:447-452)
Country: Estados Unidos
Editor: MOSBY-ELSEVIER
Citation: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, v.110, n.4, p.447-452, 2010
Rights: fechado
Identifier DOI: 10.1016/j.tripleo.2010.02.029
Address: http://dx.doi.org/10.1016/j.tripleo.2010.02.029
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Date Issue: 2010
Appears in Collections:FOP - Artigos e Materiais de Revistas Científicas

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