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Type: Artigo de periódico
Title: Studies on the total synthesis of sanglifehrin A: stereoselective synthesis of the C(29)-C(39) fragment
Author: Dias, LC
Salles, AG
Abstract: A highly stereoselective synthesis of the C(29)-C(39) fragment of the potent immunosuppressant sanglifehrin A has been accomplished by a sequence involving 16 steps (18% overall yield) from N-propionyloxazolidinone 9. Key steps are a diastereoselective hydroboration, and a diastereo selective epoxidation of an allylic alcohol followed by a 1,5-anti boron-mediated aldol reaction of methyl ketone 4 with chiral aldehyde 5. (c) 2006 Elsevier Ltd. All rights reserved.
Subject: immunosuppressant
1,5-anti aldol
1,5-asymmetric induction
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2006.01.105
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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