Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/75227
Type: Artigo de periódico
Title: Stereoselective Total Synthesis of the Potent Anti-Asthmatic Compound CMI-977 (LDP-977)
Author: Dias, LC
Farina, LS
Ferreira, MAB
Abstract: A short and efficient stereoselective total synthesis of CMI-977 (LDP-977), a potent and orally active anti-asthmatic compound, was developed. The key steps involve a highly diastereoselective Mukaiyama oxidative cyclization, which provides the trans-THF (tetrahydrofuran) unit and a Seyferth-Gilbert homologation to construct the triple bond in the target molecule. The synthesis of the key chiral building block was performed using Jacobsen hydrolytic kinetic resolution.
Subject: total synthesis
CMI-977
Mukaiyama oxidative cyclization
Jacobsen hydrolytic kinetic resolution
Seyferth-Gilbert homologation
Country: Brasil
Editor: Soc Brasileira Quimica
Rights: aberto
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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