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Type: Artigo de periódico
Title: Stereoselective synthesis of analogs of the macrolactone of isomigrastatin
Author: Dias, LC
Monteiro, GC
Amarante, GW
Conegero, LS
Finelli, FG
Abstract: An approach for the highly stereoselective synthesis of analogs of the macrolactone of isomigrastatin is described. Our optimized strategy is based on a very efficient lactone opening, a Wittig olefination reaction and a ring closing metathesis. The syntheses were accomplished in 10-11 steps and good overall yields. (C) 2011 Elsevier Ltd. All rights reserved.
Subject: Migrastatin
Tumor metastasis
Ring closing metathesis
Dihydroxilation reaction
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 53, n. 6, n. 707, n. 709, 2012.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2011.12.020
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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