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|Type:||Artigo de periódico|
|Title:||Stereoselective heck-matsuda arylations of chiral dihydrofurans with arenediazonium tetrafluoroborates; An efficient enantioselective total synthesis of (-)-isoaltholactone|
|Abstract:||The Heck-Matsuda arylation of chiral 2-(S)-hydroxymethyl dihydrofurans (endocyclic enolethers) and its derivatives, employing arenediazonium tetrafluoroborates, was developed into a highly efficient, practical and diastereoselective synthetic process. This methodology was applied to the total synthesis of the styryllactone (-)-isoaltholactone in seven steps with an overall yield of similar to 25%, from the readily available chiral 2-hydroxymethyldihydrofuran. The strategy permits the synthesis of several other aromatic analogues of isoaltholactone.|
|Editor:||Georg Thieme Verlag Kg|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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