Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/75172
Type: Artigo de periódico
Title: STREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE-HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS
Author: CAPUCCI, MS
HOFFMANN, ME
NATARAJAN, AT
Abstract: The genotoxic effects of the methylating agent streptozotocin (STZ) on Chinese hamster cells CHO-9 and V79 were evaluated. The induction of cell killing, chromosomal aberrations, sister-chromatid exchanges (SCEs) and mutations was analyzed. Comparisons were made with the the STZ aglyconic analogue N-methyl-N-nitrosourea (MNU). V79 cells were found to be more resistant than CHO-9 cells to STZ and MNU killing effects, as well as to the induction of chromosomal aberrations and SCEs; however, V79 and CHO-9 cells appeared to be equally sensitive to the induction of 6-thioguanine resistant mutants by STZ. These results suggest that an error-free mechanism that tolerates DNA methylation damage confers a resistant phenotype to V79 cells to the genotoxic effects of methylation damage.
Subject: STREPTOZOTOCIN
METHYLNITROSOUREA
CHINESE HAMSTER CELLS
CHROMOSOMAL ABERRATION
SISTER-CHROMATID EXCHANGE
MUTATION
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/0165-7992(95)90074-8
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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