Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/75019
Type: Artigo de periódico
Title: The effect of caffeine in animal models of learning and memory
Author: Angelucci, MEM
Vital, MABF
Cesario, C
Zadusky, CR
Rosalen, PL
Da Cunha, C
Abstract: In the present investigation we studied the effect of caffeine on memory task inhibitory avoidance and habituation to a new environment. Caffeine impaired retention scores in mice submitted to inhibitory avoidance and habituation when administered 30 min before training at the doses of 10-30 mg/kg. These effects cannot be explained by state-dependency since the administration of caffeine 30 min before the test session did not reverse the effect of pre-training caffeine administration, but can more probably be explained by an impairment in the acquisition or by interference with attentional processes. On the other hand, caffeine improved the inhibitory avoidance (but not habituation) retention scores when administered immediately after the training or 30 min before the test session at the doses of 1-30 mg/kg or 3-10 mg/kg, respectively. These results suggest that caffeine differentially affects the different stages of memory processing and that this effect depends on particularities of the memory task under study. (C) 1999 Elsevier Science B.V. All rights reserved.
Subject: memory
learning
caffeine
avoidance
inhibitory
(mouse)
habituation
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/S0014-2999(99)00225-3
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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