Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/74846
Type: Artigo de periódico
Title: SURAMIN ATTENUATES DYSTROPHIN-DEFICIENT CARDIOMYOPATHY IN THE mdx MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY
Author: Moreira, DD
Pereira, JA
Taniguti, APT
Matsumura, CY
Ramos, LAF
Areas, MA
Neto, HS
Marques, MJ
Abstract: Introduction: The purpose of this study was to determine the effects of suramin, an antifibrotic agent, on cardiac function and remodeling in mdx mice. Methods: mdx mice (8 months old) received intraperitoneal injections of suramin twice a week for 3 months. Control mdx mice (8 months old) were injected with saline. Results: Suramin improved the electrocardiography profile with the main corrections seen in S- to R-wave ratio, PR interval, and Q amplitude, and a significant decrease in the cardiomyopathy index. Suramin decreased myocardial fibrosis, inflammation, and myonecrosis. Conclusions: These findings suggest that suramin may be a new adjunctive therapy to help improve cardiomyopathy in DMD. Muscle Nerve48: 911-919, 2013
Subject: antifibrotic drugs
cardiomyopathy
DMD
mdx
suramin
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1002/mus.23858
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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