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Type: Artigo de periódico
Title: Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling
Author: de Araujo, MVG
Vieira, EKB
Lazaro, GS
Conegero, LS
Almeida, LE
Barreto, LS
da Costa, NB
Gimenez, IF
Abstract: In this work we prepared and characterized an inclusion complex of the dihydropteroate synthase inhibitor sulfadiazine (SDZ) in 2-hydroxypropyl-beta-cyclodextrin (HPBCD). From the phase-solubility diagram we observed an increase in the water solubility of the drug, calculating a binding constant of 1879 M(-1). The inclusion mode involves a NH(2)-in orientation of the drug in the HPBCD cavity, according to the 2D NMR (ROESY) data and confirmed by molecular modeling using the semiempirical PM6 and RM1 methods. (C) 2008 Elsevier Ltd. All rights reserved.
Subject: 2-hydroxypropyl-beta-cyclodextrin
inclusion complex
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Bioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 16, n. 10, n. 5788, n. 5794, 2008.
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2008.03.057
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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