Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/74642
Type: Artigo de periódico
Title: Subdermal implants of poly(L-lactic acid) with plasticizer: an ultrastructural study in rats
Author: Silva, DRM
Joazeiro, PP
Duek, EAR
Alberto-Rincon, MC
Abstract: Poly(L-lactic acid) (PLLA) membranes containing 7% triethylcitrate plasticizer were implanted in the subcutaneous tissue of rats, and the cellular reaction was evaluated over a period of 2-180 days. The samples were processed for conventional transmission electron microscopy. Polymorphonuclear-type cells and a fibrin network were seen within membrane pores 2 days after implantation. In subsequent samples, there was cellular infiltration, which consisted mainly of fibroblasts, macrophages and multinuclear giant cells embedded in an abundant extracellular matrix containing a network of collagen fibers and blood vessels. At 90 and 180 days after implantation, a high density of voluminous phagocytic cells with a large number of endocytic polymer fragments within their cytoplasm was seen. These results show that PLLA membranes can support connective tissue proliferation and remodeling, which are important properties for successful bio-protheses.
Subject: PLLA
subcutaneous tissue
plasticizer
cellular invasion
phagocytosis
Country: Holanda
Editor: Vsp Bv
Rights: fechado
Identifier DOI: 10.1163/156856206774879018
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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