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Type: Artigo de periódico
Title: Statistical aspects in physical mapping application to the genome of O-oeni strain GM
Author: Goncalves, L
Ze-Ze, L
Pinheiro, HP
Amaral-Turkman, MA
Abstract: This work addresses issues around physical maps, in particular, for circular genomes. The overlapping relationship between two fragments obtained by applying two different restriction enzymes, separately, is classified as nonoverlapping, partial overlapping, and total overlapping. A double partial overlapping can also appear in a particular situation. Taking into account DNA fragment lengths and under the assumption that the left-hand endpoints of the two restriction fragments are independent random variables, each of which with a uniform distribution along a circular genome, we present expressions for prior probabilities of those events. This information is combined with hybridization data via Bayes' theorem, in order to evaluate corresponding posterior probabilities. Additionally, we explore a sensitivity analysis to quantify the effect of length variation in the results.
Subject: Bayes' theorem
overlap probabilities
physical mapping
Country: Inglaterra
Editor: Blackwell Publishing
Citation: Biometrics. Blackwell Publishing, v. 61, n. 2, n. 481, n. 487, 2005.
Rights: fechado
Identifier DOI: 10.1111/j.1541-0420.2005.00326.x
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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