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Type: Artigo de periódico
Title: Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells
Author: Machado-Neto, JA
Campos, PD
Favaro, P
Lazarini, M
Lorand-Metze, I
Costa, FF
Saad, STO
Traina, F
Abstract: Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1 levels were observed in proliferating hematopoietic cells, in high-risk MDS and acute leukemia cells. In addition, Stathmin 1 silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that Stathmin 1 expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of Stathmin 1 in hematological malignancies. (C) 2013 Elsevier Ltd. All rights reserved.
Subject: Stathmin 1
Myelodysplastic syndromes
Acute myeloid leukemia
Acute lymphoid leukemia
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Leukemia Research. Pergamon-elsevier Science Ltd, v. 38, n. 2, n. 251, n. 257, 2014.
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2013.11.013
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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