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Type: Artigo de periódico
Title: Spray-dried chitosan microspheres as a pDNA carrier
Author: Oliveira, BF
Santana, MHA
Re, MI
Abstract: Spray-dried chitosan microparticles with controlled size were prepared and crosslinked with the biocompatible reactant d,l -glyceraldehyde. Glutaraldehyde, the conventional cross-linking agent for proteins, was used as a control. The crosslinking degree was characterized through thermal analysis, X-ray diffraction, and infrared spectroscopy. In addition, the crosslinking effects were analyzed in terms of particle size, swelling capability, and surface charge. By properly choosing d,l -glyceraldehyde concentration and crosslink time, a high degree of control was achieved over the physical properties of particles. Yields around 78% as well as images obtained through fluorescence microscopy demonstrated the capability of the crosslinked chitosan microspheres to pDNA complexation.
Subject: glyceraldehyde
chitosan microspheres
spray drying
Country: EUA
Editor: Taylor & Francis Inc
Rights: fechado
Identifier DOI: 10.1080/07373930600564431
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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