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|Type:||Artigo de periódico|
|Title:||Six-minute walk test for the evaluation of pulmonary disease severity in scleroderma patients|
|Abstract:||Background: Pulmonary involvement is the leading cause of systemic sclerosis (SSc)-related deaths. A simple test to evaluate exercise capacity is the 6-min walk test (6MWT), and the walk distance is used as a primary outcome in clinical trials. Hemoglobin desaturation during a 6MWT is predictive of mortality in patients with primary pulmonary hypertension. Our objectives were to evaluate the walk distance and resting oxygen saturation - oxygen saturation after the 6-min period (Delta Sat) during the 6MWT in patients with SSc, and to establish correlations between the 6MWT results and other clinical variables. Methods: We analyzed 110 SSc patients. Delta Sat was defined as a fall of end-of-test saturation >= 4%. Clinical and demographic data were collected. All the patients were submitted to chest radiographs and high-resolution CT (HRCT) and underwent pulmonary function testing and echocardiography, and the presence of autoantibodies was determined. Results: The variables associated with a walk distance < 400 m (p < 0.05) were age, dyspnea index, fibrosis on radiography, pulmonary arterial systolic pressure (PASP) >= 30 mm Hg, and desaturation. The variables associated with Delta Sat (p < 0.05) were age, positive anti-Scl-70 autoantibody, dyspnea index, fibrosis on radiography, FVC < 80% of predicted, PASP 2: 30 mm Hg, and ground-glass or reticular opacities on HRCT. In the multivariate logistic regression analysis, three variables were significant when tested with walk distance: age, race, and dyspnea index; four variables were significant when tested with Delta Sat: age, dyspnea index, positive anti-Sel-70 autoantibody, and FVC < 80% of predicted. Conclusions: Desaturation during a 6MWT provides additional information regarding severity of disease in seleroderma patients with pulmonary manifestations.|
|Editor:||Amer Coll Chest Physicians|
|Citation:||Chest. Amer Coll Chest Physicians, v. 131, n. 1, n. 217, n. 222, 2007.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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