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dc.contributor.CRUESPUniversidade Estadual de Campinaspt
dc.typeArtigo de periódicopt
dc.titleSingle intraoperative application versus postoperative mitomycin C eye drops in pterygium surgerypt
dc.contributor.authorCardillo, JApt
dc.contributor.authorAlves, MRpt
dc.contributor.authorAmbrosio, LEpt
dc.contributor.authorPoterio, MBpt
dc.contributor.authorJose, NKpt
unicamp.authorUNIV CAMPINAS,SCH MED,DEPT OPHTHALMOL,CAMPINAS,SP,BRAZILpt
dc.subject.wosConjunctival Autograft Transplantationpt
dc.subject.wosInstillationpt
dc.description.abstractPurpose: To determine the minimum effective dosage, most effective route of administration and long-term effects of mitomycin C for prevention of recurrence after pterygium surgery. Methods: In a prospective, masked study, 227 patients undergoing surgery for primary pterygia were assigned randomly to five groups: group 1 received a single intraoperative application of 0.2 mg/ml mitomycin C for 3 minutes; group 2 received a single intraoperative application of 0.4 mg/ml mitomycin C for 3 minutes; group 3 received mitomycin C eye drops 0.2 mg/ml three times daily for 7 days; group 4 received mitomycin C eye drops 0.4 mglml three times daily for 14 days; group 5 acted as a control (surgery alone), Results: After a mean follow-up time of 28 months, recurrence rates of 6.66%, 4.08%, 4.26%, 4.44%, and 29.27%, respectively, were observed. Statistical analysis showed significant differences between groups receiving mitomycin C and the control (P less than or equal to 0.001). There was no statistical difference among treated groups (P greater than or equal to 0.0681). No complications of therapy were observed. Conclusion: These results support the efficacy and relative safety of a single, low-concentration, intraoperative application of mitomycin C in pterygium surgery together with the use of a conjunctival flap, avoiding excessive cauterization of the sclera and leaving bare sclera.pt
dc.relation.ispartofOphthalmologypt_BR
dc.relation.ispartofabbreviationOphthalmologypt
dc.publisher.cityPhiladelphiapt
dc.publisherLippincott-raven Publpt
dc.date.issued1995pt
dc.date.monthofcirculationDECpt
dc.identifier.citationOphthalmology. Lippincott-raven Publ, v. 102, n. 12, n. 1949, n. 1952, 1995.pt
dc.language.isoenpt
dc.description.volume102pt
dc.description.issuenumber12pt
dc.description.initialpage1949pt
dc.description.lastpage1952pt
dc.rightsfechadopt
dc.sourceWeb of Sciencept
dc.identifier.issn0161-6420pt
dc.identifier.wosidWOS:A1995TL78300040pt
dc.date.available2014-12-16T11:36:48Z
dc.date.available2015-11-26T16:25:30Z-
dc.date.accessioned2014-12-16T11:36:48Z
dc.date.accessioned2015-11-26T16:25:30Z-
dc.description.provenanceMade available in DSpace on 2014-12-16T11:36:48Z (GMT). No. of bitstreams: 1 WOSA1995TL78300040.pdf: 495236 bytes, checksum: 95dd94ff77a1b169191b67120be743d3 (MD5) Previous issue date: 1995en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:25:30Z (GMT). No. of bitstreams: 2 WOSA1995TL78300040.pdf: 495236 bytes, checksum: 95dd94ff77a1b169191b67120be743d3 (MD5) WOSA1995TL78300040.pdf.txt: 19284 bytes, checksum: 20c234c60472bda006a2e3530ca997bd (MD5) Previous issue date: 1995en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74253pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/74253
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74253-
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