Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/74081
Type: Artigo de periódico
Title: Synthesis and rational design of anti-inflammatory compounds: N-phenyl-cyclohexenyl sulfonamide derivatives
Author: Lloret, GR
Neto, AC
Rittner, R
Bitencourt, M
Freitas, MP
Aquino, NS
Abstract: The synthesis of (+/-)-ethyl 6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (5n) has been reproduced from a method previously described and served as the background for the preparation of a nitro derivative, potentially useful as an anti-inflammatory agent. Furthermore, a structure-based QSAR analysis of a series of N-arylsulfamoyl congeners derived a highly predictive model for the activities of novel small-molecule inhibitors of NO and cytokine production, whose preparation may be successfully achieved according to a similar procedure as above. Copyright (C) 2009 John Wiley & Sons, Ltd.
Subject: anti-inflammatory compounds
MIA-QSAR
N-arylsulfamoyl derivatives
Country: Inglaterra
Editor: John Wiley & Sons Ltd
Rights: fechado
Identifier DOI: 10.1002/poc.1575
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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