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Type: Artigo de periódico
Title: Synthesis and Evaluation of New beta-Carboline-3-(4-benzylidene)-4H- oxazol-5-one Derivatives as Antitumor Agents
Author: Savariz, FC
Foglio, MA
de Carvalho, JE
Ruiz, ALTG
Duarte, MCT
da Rosa, MF
Meyer, E
Sarragiotto, MH
Abstract: In the present work, we report the synthesis and in vitro anticancer and antimicrobial activity evaluation of a new series of 1-substituted-beta-carboline derivatives bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4-methoxyphenyl)- 9H-beta-carbolin-3-yl]-4-(benzylidene)-4H-oxazol-5-one (11) was the most active derivative, exhibiting a potent cytotoxic activity against glioma (U251), prostate (PC-3) and ovarian (OVCAR-03) cancer cell lines with IC50 values of 0.48, 1.50 and 1.07 mu M, respectively. An in silico study of the ADME properties of the novel synthesized beta-carboline derivatives was also performed.
Subject: beta-carboline
cytotoxic activity
antimicrobial activity
Country: Suíça
Editor: Mdpi Ag
Citation: Molecules. Mdpi Ag, v. 17, n. 5, n. 6100, n. 6113, 2012.
Rights: aberto
Identifier DOI: 10.3390/molecules17056100
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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