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Type: Artigo de periódico
Title: Synthesis and characterization of inclusion complex of the vasodilator drug minoxidil with beta-cyclodextrin
Author: Calderini, A
Pessine, FBT
Abstract: The inclusion complex of beta-cyclodextrin and minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was synthesized using two methods-kneading and freeze-drying-and characterized by UV-Vis spectroscopy, infrared spectroscopy, powder X-ray diffractometry, differential scanning calorimetry, thermal gravimetric analysis, and nuclear magnetic resonance spectroscopy. These techniques have demonstrated the existence of inclusion compound formation between the host and guest with a molar ratio of 1:1. The studies of solubility and the data obtained by nuclear magnetic resonance spectroscopy showed a weak interaction between the guest and the cyclodextrin molecules in solution.
Subject: minoxidil
inclusion complex
Country: Holanda
Editor: Springer
Citation: Journal Of Inclusion Phenomena And Macrocyclic Chemistry. Springer, v. 60, n. 41732, n. 369, n. 377, 2008.
Rights: fechado
Identifier DOI: 10.1007/s10847-007-9387-z
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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