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Type: Artigo de periódico
Title: Synthesis and biological activities of N,N-dimethyl-2-propen-1-amine derivatives
Author: DeConti, R
Gimenez, SMN
Haun, M
Pilli, RA
DeCastro, SL
Duran, N
Abstract: The synthesis of several 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine derivatives is described. These compounds are potential trypanocide agents with relative low acute toxicities. The inhibition of growth of Escherichia cell by these drugs with different para-substitution on the phenyl moiety and their trypanocidal activities against epimastigote from Trypanosoma cruzi were investigated.
Subject: Chagas's disease
Trypanosoma cruzi
Country: França
Editor: Editions Scientifiques Elsevier
Citation: European Journal Of Medicinal Chemistry. Editions Scientifiques Elsevier, v. 31, n. 11, n. 915, n. 918, 1996.
Rights: fechado
Identifier DOI: 10.1016/S0223-5234(97)89856-X
Date Issue: 1996
Appears in Collections:Unicamp - Artigos e Outros Documentos

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