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Type: Artigo de periódico
Title: Synthesis and Anti-Paracoccidioides Activity of Calix[n]arenes
Author: de Oliveira, MC
Reis, FS
de Fatima, A
Magalhaes, TFF
da Silva, DL
Porto, RR
Watanabe, GA
Martins, CVB
da Silva, DL
Ruiz, ALTG
Fernandes, SA
de Carvalho, JE
de Resende-Stoianoff, MA
Abstract: Fungi are some of the most neglected pathogens in terms of new drug discovery. Paracoccidioidomycosis, an endemic disease to South America, is caused by dimorphic fungi of Paracoccidioides genus. Reasonable citotoxicity, limited efficacy, and frequent use of current commercial antifungals have led to the emergence of resistance. Thus, the development of new antifungals with more selectivity and large spectrum of action is mandatory. In this work, six calix[n]arenes were synthesized and their activity explored against seven isolates of P. brasiliensis and P. lutzii. p-tert-Butylcalix[4] arene (CX1) was the most potent compound against fungal cells and exhibited the lowest toxicity on healthy mammalian cells (V79, hamster lung and MDCK, dog kidney). This is the first report on the effect of calix[n] arenes as growth inhibitors of Paracoccidioides fungi.
Subject: Calix[n]arenes
Paracoccidioides genus
Dimorphic fungi
Mammalian cells
Country: Emirados Árabes Unidos
Editor: Bentham Science Publ Ltd
Citation: Letters In Drug Design & Discovery. Bentham Science Publ Ltd, v. 9, n. 1, n. 30, n. 36, 2012.
Rights: fechado
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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