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|Type:||Artigo de periódico|
|Title:||Syntheses of some 4-anilinoquinazoline derivatives|
|Abstract:||Some 4-N-(3'- or 4'-substituted-phenyl)amino-6,7-dimethoxyquinazolines and the corresponding unsubstituted compounds were synthesized from 2-amino-4,5-dimethoxybenzoic acid and the appropriate substituted anilines. Other related quinazolines or their synthetic intermediates were also obtained. A large number of the described quinazolines are new compounds, while the remaining were prepared by a more efficient procedure. The main goal for the synthesis of these compounds comes from the fact that the 4-anilinoquinazoline pharmacophore is an important unit, which is found among the ATP-competitive inhibitors of several protein kinase enzymes.|
|Editor:||Georg Thieme Verlag Kg|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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