Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/738
Type: Artigo de periódico
Title: Antibothropic action of Casearia sylvestris Sw. (flacourtiaceae) extracts
Author: CINTRA-FRANCISCHINELLI, M.
SILVA, M. G.
ANDREO-FILHO, N.
GERENUTTI, M.
CINTRA, A. C. O.
GIGLIO, J. R.
LEITE, G. B.
CRUZ-HOEFLING, M. A.
RODRIGUES-SIMIONI, L.
OSHIMA-FRANCO, Y.
Abstract: Casearia sylvestris Sw., popularly known in Brazil as `guacatonga`, has been used as antitumor, antiseptic, antiulcer, local anaesthetic and healer in folk medicine. Snakebite envenomation by Bothrops jararacussu (Bjssu) constitutes a relevant public health hazard capable of inducing serious local damage in victims. This study examined the pharmacological action of apolar and polar C sylvestris leaf extracts in reverting the neuromuscular blockade and myonecrosis, which is induced by Bjssu venom and its major toxin bothropstoxin-I on the mouse phrenic nerve-diaphragm preparations. The polar methanol extract (ME) was by far the most efficacious. ME not only prevented myonecrosis and abolished the blockade, but also increased ACh release. Such facilitation in neuromuscular transmission was observed with ME alone, but was accentuated in preparations incubated with ME plus venom or toxin. This established synergy opens an interesting point of investigation because the venom or toxin in contact with ME changes from a blocking to a facilitating effect. It is suggested that rutin, known to have potent antioxidant properties, and one of the components present in the ME, could have a role in the observed effects. Since commercial rutin did not reproduce the ME effects, it is likely that a rutin-containing phytocomplex is neutralizing the bothropic envenoming effects. Copyright (C) 2008 John Wiley & Sons, Ltd.
Subject: medicinal plant extracts
myotoxicity
neuromuscular junction
neurotoxicity
pharmacognosy
Country: Inglaterra
Editor: JOHN WILEY & SONS LTD
Citation: PHYTOTHERAPY RESEARCH, v.22, n.6, p.784-790, 2008
Rights: fechado
Identifier DOI: 10.1002/ptr.2365
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000256959100011&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.1002/ptr.2365
Date Issue: 2008
Appears in Collections:IB - Artigos e Materiais de Revistas Científicas

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