Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/73786
Type: Artigo de periódico
Title: THE EFFECTS AND MOLAR POTENCY OF ILOPROST, U46619 AND SODIUM-NITROPRUSSIDE ON CAPSULAR AND VASCULAR SMOOTH-MUSCLE OF THE ISOLATED-PERFUSED CANINE SPLEEN
Author: GRASSIKASSISSE, DM
ANTUNES, E
SANCHO, EV
WITHRINGTON, PG
DENUCCI, G
Abstract: The isolated canine spleen was perfused at constant flow with continuous recording of splenic arterial perfusion pressure (SAPP) and spleen weight, Intra-arterial injections of the thromboxane A(2) (TXA(2)) mimetic U46619 caused dose-related increases in splenic arterial perfusion pressure (SAPP) of short duration (ED(50) 0.31 nmol). There were very small changes in spleen weight accompanying any of the vasoconstrictor responses to U46619. The stable analogue of prostacyclin, iloprost, caused dose-dependent reductions in SAPP (ED(50) 1.3 nmol) indicating vasodilatation. There were no changes in spleen weight to any doses of iloprost indicating a lack of action on capsular smooth muscle. Similarly, the nitric oxide (NO) mimetic sodium nitroprusside caused dose-related reductions in SAPP of short duration (ED(50) 5.8 nmol). No changes in spleen weight accompanied splenic vasodilator responses to any dose of sodium nitroprusside (SNP). The results indicate the potential actions and intrinsic potency of three endogenous vasoactive substances and provide information about their relative roles in the control of the splenic microcirculation in situations when they are released.
Country: Escócia
Editor: Churchill Livingstone
Rights: fechado
Identifier DOI: 10.1016/0952-3278(94)90061-2
Date Issue: 1994
Appears in Collections:Unicamp - Artigos e Outros Documentos

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