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Type: Artigo de periódico
Title: The effect of treatment with crotapotin on the evolution of experimental autoimmune neuritis induced in Lewis rats
Author: Castro, FR
Farias, AS
Proenca, PLF
de La Hoz, C
Langone, F
Oliveira, EC
Toyama, MH
Marangoni, S
Santos, LMB
Abstract: Biomedical research in which venom components are being investigated for their potential as novel therapeutic agents has emerged as an interesting option. Crotapotin, which is purified from the venom of the rattlesnake Crotalus durissus terrificus, has been described as an anti-inflammatory agent that acts on the innate arm of the immune response. Here we have demonstrated that intraperitoneal administration of crotapotin significantly reduces the severity of experimental autoimmune neuritis (EAN), an experimental model for Guillain-Barre syndrome. The reduction of the severity of the disease is associated with a reduction in the mononuclear cells infiltrating the sciatic nerve and a significant decrease in the lymphocyte proliferative response to neuritogenic peptide. (c) 2006 Elsevier Ltd. All rights reserved.
Subject: demyelination
T-cell activation
experimental autoimmune neuritis
Guillain-Barre syndrome
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2006.09.028
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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