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Type: Artigo de periódico
Title: The effect of topiramate on cognitive fMRI
Author: Yasuda, CL
Centeno, M
Vollmar, C
Stretton, J
Symms, M
Cendes, F
Mehta, MA
Thompson, P
Duncan, JS
Koepp, MJ
Abstract: Purpose: Topiramate (TPM) is known to cause language impairment in healthy volunteers and patients with epilepsy. We assessed the effects of TPM on functional language networks in both patients with focal epilepsies and healthy controls using functional magnetic resonance imaging (fMRI). Methods: We obtained fMRI data in 24 controls and 35 patients with frontal lobe epilepsy using a simple verbal fluency (VF) paradigm. Eight of the 35 patients were treated with TPM in polytherapy. We compared cognitive task related activations and de-activations in patients taking TPM with patients taking other AEDs and healthy controls. In a longitudinal pilot study with VF-fMRI paradigm, we studied two patients with focal epilepsies twice, prior to starting and on stable doses of TPM, two patients twice, before and after tapering TPM completely and two healthy controls twice, before and after single doses of 200 mg TPM. Key findings: Cross sectional analyses of VF-fMRI showed a reduction in the task-related deactivation of the default mode network (DMN) in patients taking TPM. The longitudinal study corroborated these findings as both chronic administration and a single dose of TPM were associated with impaired categorical verbal fluency and disruption of task-related deactivations. Significance: Similar neuropsychological and fMRI findings in patients and healthy controls indicate a specific effect of TPM in default mode network areas that may be essential components of the language network. Our preliminary data suggest a mechanism by which TPM impairs cognitive processing during language function and highlights the sensitivity of fMRI to detect the effects of AEDs on cognitive brain networks. (C) 2013 Elsevier B.V. All rights reserved.
Subject: Topiramate
Default mode network
Country: Holanda
Editor: Elsevier Science Bv
Citation: Epilepsy Research. Elsevier Science Bv, v. 105, n. 41671, n. 250, n. 255, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.eplepsyres.2012.12.007
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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